{
    "project_title": "Wheatgrass molecules ( PV ) Ai Report.docx",
    "exported_at": "2026-08-02T10:13:17Z",
    "relationships": [
        {
            "subject": "5-Fluorouracil",
            "subject_type": "Drug",
            "relationship": "ASSOCIATED_WITH",
            "object": "angioneurotic edema",
            "object_type": "Outcome",
            "evidence": "the patient developed angioneurotic edema/angioedema during continuous infusion 5-FU after prior courses",
            "confidence": 0.95
        },
        {
            "subject": "5-Fluorouracil",
            "subject_type": "Drug",
            "relationship": "ASSOCIATED_WITH",
            "object": "oral mucositis",
            "object_type": "Outcome",
            "evidence": "Oral mucous membrane disorders in 69.2% intra-arterial arm",
            "confidence": 0.92
        },
        {
            "subject": "5-Fluorouracil",
            "subject_type": "Drug",
            "relationship": "ASSOCIATED_WITH",
            "object": "neutropenia",
            "object_type": "Outcome",
            "evidence": "milder neutropenia systemically",
            "confidence": 0.9
        },
        {
            "subject": "5-Fluorouracil",
            "subject_type": "Drug",
            "relationship": "ASSOCIATED_WITH",
            "object": "myelotoxicity",
            "object_type": "Outcome",
            "evidence": "the main toxicities were myelotoxicity, nausea, and vomiting",
            "confidence": 0.9
        },
        {
            "subject": "5-Fluorouracil",
            "subject_type": "Drug",
            "relationship": "ASSOCIATED_WITH",
            "object": "nausea",
            "object_type": "Outcome",
            "evidence": "the main toxicities were myelotoxicity, nausea, and vomiting",
            "confidence": 0.92
        },
        {
            "subject": "5-Fluorouracil",
            "subject_type": "Drug",
            "relationship": "ASSOCIATED_WITH",
            "object": "vomiting",
            "object_type": "Outcome",
            "evidence": "the main toxicities were myelotoxicity, nausea, and vomiting",
            "confidence": 0.92
        },
        {
            "subject": "5-Fluorouracil",
            "subject_type": "Drug",
            "relationship": "ASSOCIATED_WITH",
            "object": "facial palsy",
            "object_type": "Outcome",
            "evidence": "facial palsy complication occurred in one patient",
            "confidence": 0.88
        },
        {
            "subject": "5-Fluorouracil",
            "subject_type": "Drug",
            "relationship": "ASSOCIATED_WITH",
            "object": "leukopenia",
            "object_type": "Outcome",
            "evidence": "Main adverse effects were leukopenia and mucositis",
            "confidence": 0.9
        },
        {
            "subject": "5-Fluorouracil",
            "subject_type": "Drug",
            "relationship": "ASSOCIATED_WITH",
            "object": "mucositis",
            "object_type": "Outcome",
            "evidence": "Main adverse effects were leukopenia and mucositis",
            "confidence": 0.92
        },
        {
            "subject": "5-Fluorouracil",
            "subject_type": "Drug",
            "relationship": "ASSOCIATED_WITH",
            "object": "thrombocytopenia",
            "object_type": "Outcome",
            "evidence": "Thrombocytopenia, anorexia, nausea, vomiting, stomatitis, SIADH",
            "confidence": 0.88
        },
        {
            "subject": "5-Fluorouracil",
            "subject_type": "Drug",
            "relationship": "ASSOCIATED_WITH",
            "object": "anorexia",
            "object_type": "Outcome",
            "evidence": "Thrombocytopenia, anorexia, nausea, vomiting, stomatitis, SIADH",
            "confidence": 0.88
        },
        {
            "subject": "5-Fluorouracil",
            "subject_type": "Drug",
            "relationship": "ASSOCIATED_WITH",
            "object": "stomatitis",
            "object_type": "Outcome",
            "evidence": "Thrombocytopenia, anorexia, nausea, vomiting, stomatitis, SIADH",
            "confidence": 0.9
        },
        {
            "subject": "5-Fluorouracil",
            "subject_type": "Drug",
            "relationship": "TREATS",
            "object": "oral cancer",
            "object_type": "Disease",
            "evidence": "all oral carcinoma patients achieved CR",
            "confidence": 0.85
        },
        {
            "subject": "Chlorophyllin",
            "subject_type": "Molecule",
            "relationship": "INHIBITS",
            "object": "NF-κB signaling pathway",
            "object_type": "Pathway",
            "evidence": "Inhibited NF-κB and induced intrinsic apoptosis in hamster buccal pouch carcinogenesis",
            "confidence": 0.9
        },
        {
            "subject": "Chlorophyllin",
            "subject_type": "Molecule",
            "relationship": "TESTED_IN",
            "object": "hamster model of oral oncogenesis",
            "object_type": "ExperimentalModel",
            "evidence": "Dietary chlorophyllin inhibits the canonical NF-κB signaling pathway and induces intrinsic apoptosis in a hamster model of oral oncogenesis",
            "confidence": 0.95
        },
        {
            "subject": "Quercetin",
            "subject_type": "Molecule",
            "relationship": "INHIBITS",
            "object": "CYP3A4",
            "object_type": "Protein",
            "evidence": "Quercetin can inhibit CYP3A4, CYP2C19, OATPs, BCRP, and MRP2",
            "confidence": 0.92
        },
        {
            "subject": "Quercetin",
            "subject_type": "Molecule",
            "relationship": "INHIBITS",
            "object": "CYP2C19",
            "object_type": "Protein",
            "evidence": "Quercetin can inhibit CYP3A4, CYP2C19, OATPs, BCRP, and MRP2",
            "confidence": 0.92
        }
    ]
}