{
    "project_title": "Wheatgrass molecules systematic review and meta-analysis ( clinical )  Ai Report.docx",
    "exported_at": "2026-08-02T10:06:04Z",
    "relationships": [
        {
            "subject": "chlorophyll",
            "subject_type": "Molecule",
            "relationship": "ASSOCIATED_WITH",
            "object": "oral cancer",
            "object_type": "Disease",
            "evidence": "Intervention (PICO formulation): In adults with oral cancer or oral potentially malignant disorders (OPMDs), does local delivery (oral strip/film/lozenge) of chlorophyll or chlorophyllin...alter clinical, histologic, or biomarker outcomes",
            "confidence": 0.95
        },
        {
            "subject": "chlorophyllin",
            "subject_type": "Molecule",
            "relationship": "ASSOCIATED_WITH",
            "object": "oral cancer",
            "object_type": "Disease",
            "evidence": "Intervention (PICO formulation): In adults with oral cancer or oral potentially malignant disorders (OPMDs), does local delivery (oral strip/film/lozenge) of chlorophyll or chlorophyllin...alter clinical, histologic, or biomarker outcomes",
            "confidence": 0.95
        },
        {
            "subject": "apigenin",
            "subject_type": "Molecule",
            "relationship": "ASSOCIATED_WITH",
            "object": "oral cancer",
            "object_type": "Disease",
            "evidence": "Intervention (PICO formulation): In adults with oral cancer or oral potentially malignant disorders (OPMDs), does local delivery...of apigenin (or flavonoid-rich extracts)...alter clinical, histologic, or biomarker outcomes",
            "confidence": 0.95
        },
        {
            "subject": "quercetin",
            "subject_type": "Molecule",
            "relationship": "ASSOCIATED_WITH",
            "object": "oral cancer",
            "object_type": "Disease",
            "evidence": "Intervention (PICO formulation): In adults with oral cancer or oral potentially malignant disorders (OPMDs), does local delivery...of quercetin/rutin...alter clinical, histologic, or biomarker outcomes",
            "confidence": 0.95
        },
        {
            "subject": "rutin",
            "subject_type": "Molecule",
            "relationship": "ASSOCIATED_WITH",
            "object": "oral cancer",
            "object_type": "Disease",
            "evidence": "Intervention (PICO formulation): In adults with oral cancer or oral potentially malignant disorders (OPMDs), does local delivery...of quercetin/rutin...alter clinical, histologic, or biomarker outcomes",
            "confidence": 0.95
        },
        {
            "subject": "abscisic acid",
            "subject_type": "Molecule",
            "relationship": "ASSOCIATED_WITH",
            "object": "oral cancer",
            "object_type": "Disease",
            "evidence": "Intervention (PICO formulation): In adults with oral cancer or oral potentially malignant disorders (OPMDs), does local delivery...of abscisic acid...alter clinical, histologic, or biomarker outcomes",
            "confidence": 0.95
        },
        {
            "subject": "apigenin",
            "subject_type": "Molecule",
            "relationship": "MODULATES",
            "object": "NF-κB",
            "object_type": "Protein",
            "evidence": "apigenin, quercetin, and rutin have demonstrated anti-proliferative, pro-apoptotic, anti‑inflammatory and anti‑invasion effects in oral-cancer cellular and animal models, frequently modulating NF-κB, EGFR/STAT3, PI3K/Akt and MMP pathways",
            "confidence": 0.9
        },
        {
            "subject": "quercetin",
            "subject_type": "Molecule",
            "relationship": "MODULATES",
            "object": "NF-κB",
            "object_type": "Protein",
            "evidence": "apigenin, quercetin, and rutin have demonstrated anti-proliferative, pro-apoptotic, anti‑inflammatory and anti‑invasion effects in oral-cancer cellular and animal models, frequently modulating NF-κB, EGFR/STAT3, PI3K/Akt and MMP pathways",
            "confidence": 0.9
        },
        {
            "subject": "rutin",
            "subject_type": "Molecule",
            "relationship": "MODULATES",
            "object": "NF-κB",
            "object_type": "Protein",
            "evidence": "apigenin, quercetin, and rutin have demonstrated anti-proliferative, pro-apoptotic, anti‑inflammatory and anti‑invasion effects in oral-cancer cellular and animal models, frequently modulating NF-κB, EGFR/STAT3, PI3K/Akt and MMP pathways",
            "confidence": 0.9
        },
        {
            "subject": "apigenin",
            "subject_type": "Molecule",
            "relationship": "MODULATES",
            "object": "STAT3",
            "object_type": "Protein",
            "evidence": "apigenin, quercetin, and rutin have demonstrated anti-proliferative, pro-apoptotic, anti‑inflammatory and anti‑invasion effects in oral-cancer cellular and animal models, frequently modulating NF-κB, EGFR/STAT3, PI3K/Akt and MMP pathways",
            "confidence": 0.9
        },
        {
            "subject": "quercetin",
            "subject_type": "Molecule",
            "relationship": "MODULATES",
            "object": "STAT3",
            "object_type": "Protein",
            "evidence": "apigenin, quercetin, and rutin have demonstrated anti-proliferative, pro-apoptotic, anti‑inflammatory and anti‑invasion effects in oral-cancer cellular and animal models, frequently modulating NF-κB, EGFR/STAT3, PI3K/Akt and MMP pathways",
            "confidence": 0.9
        },
        {
            "subject": "rutin",
            "subject_type": "Molecule",
            "relationship": "MODULATES",
            "object": "STAT3",
            "object_type": "Protein",
            "evidence": "apigenin, quercetin, and rutin have demonstrated anti-proliferative, pro-apoptotic, anti‑inflammatory and anti‑invasion effects in oral-cancer cellular and animal models, frequently modulating NF-κB, EGFR/STAT3, PI3K/Akt and MMP pathways",
            "confidence": 0.9
        },
        {
            "subject": "apigenin",
            "subject_type": "Molecule",
            "relationship": "MODULATES",
            "object": "EGFR",
            "object_type": "Protein",
            "evidence": "apigenin, quercetin, and rutin have demonstrated anti-proliferative, pro-apoptotic, anti‑inflammatory and anti‑invasion effects in oral-cancer cellular and animal models, frequently modulating NF-κB, EGFR/STAT3, PI3K/Akt and MMP pathways",
            "confidence": 0.9
        },
        {
            "subject": "quercetin",
            "subject_type": "Molecule",
            "relationship": "MODULATES",
            "object": "EGFR",
            "object_type": "Protein",
            "evidence": "apigenin, quercetin, and rutin have demonstrated anti-proliferative, pro-apoptotic, anti‑inflammatory and anti‑invasion effects in oral-cancer cellular and animal models, frequently modulating NF-κB, EGFR/STAT3, PI3K/Akt and MMP pathways",
            "confidence": 0.9
        },
        {
            "subject": "rutin",
            "subject_type": "Molecule",
            "relationship": "MODULATES",
            "object": "EGFR",
            "object_type": "Protein",
            "evidence": "apigenin, quercetin, and rutin have demonstrated anti-proliferative, pro-apoptotic, anti‑inflammatory and anti‑invasion effects in oral-cancer cellular and animal models, frequently modulating NF-κB, EGFR/STAT3, PI3K/Akt and MMP pathways",
            "confidence": 0.9
        },
        {
            "subject": "apigenin",
            "subject_type": "Molecule",
            "relationship": "MODULATES",
            "object": "PI3K/Akt",
            "object_type": "Pathway",
            "evidence": "apigenin, quercetin, and rutin have demonstrated anti-proliferative, pro-apoptotic, anti‑inflammatory and anti‑invasion effects in oral-cancer cellular and animal models, frequently modulating NF-κB, EGFR/STAT3, PI3K/Akt and MMP pathways",
            "confidence": 0.9
        },
        {
            "subject": "quercetin",
            "subject_type": "Molecule",
            "relationship": "MODULATES",
            "object": "PI3K/Akt",
            "object_type": "Pathway",
            "evidence": "apigenin, quercetin, and rutin have demonstrated anti-proliferative, pro-apoptotic, anti‑inflammatory and anti‑invasion effects in oral-cancer cellular and animal models, frequently modulating NF-κB, EGFR/STAT3, PI3K/Akt and MMP pathways",
            "confidence": 0.9
        },
        {
            "subject": "rutin",
            "subject_type": "Molecule",
            "relationship": "MODULATES",
            "object": "PI3K/Akt",
            "object_type": "Pathway",
            "evidence": "apigenin, quercetin, and rutin have demonstrated anti-proliferative, pro-apoptotic, anti‑inflammatory and anti‑invasion effects in oral-cancer cellular and animal models, frequently modulating NF-κB, EGFR/STAT3, PI3K/Akt and MMP pathways",
            "confidence": 0.9
        },
        {
            "subject": "apigenin",
            "subject_type": "Molecule",
            "relationship": "MODULATES",
            "object": "MMP",
            "object_type": "Protein",
            "evidence": "apigenin, quercetin, and rutin have demonstrated anti-proliferative, pro-apoptotic, anti‑inflammatory and anti‑invasion effects in oral-cancer cellular and animal models, frequently modulating NF-κB, EGFR/STAT3, PI3K/Akt and MMP pathways",
            "confidence": 0.9
        },
        {
            "subject": "quercetin",
            "subject_type": "Molecule",
            "relationship": "MODULATES",
            "object": "MMP",
            "object_type": "Protein",
            "evidence": "apigenin, quercetin, and rutin have demonstrated anti-proliferative, pro-apoptotic, anti‑inflammatory and anti‑invasion effects in oral-cancer cellular and animal models, frequently modulating NF-κB, EGFR/STAT3, PI3K/Akt and MMP pathways",
            "confidence": 0.9
        },
        {
            "subject": "rutin",
            "subject_type": "Molecule",
            "relationship": "MODULATES",
            "object": "MMP",
            "object_type": "Protein",
            "evidence": "apigenin, quercetin, and rutin have demonstrated anti-proliferative, pro-apoptotic, anti‑inflammatory and anti‑invasion effects in oral-cancer cellular and animal models, frequently modulating NF-κB, EGFR/STAT3, PI3K/Akt and MMP pathways",
            "confidence": 0.9
        },
        {
            "subject": "chlorophyllin oral strip",
            "subject_type": "Formulation",
            "relationship": "CONTAINS",
            "object": "chlorophyllin",
            "object_type": "Molecule",
            "evidence": "Chlorophyllin oral strip, dose/frequency/duration",
            "confidence": 1
        },
        {
            "subject": "quercetin/rutin mucoadhesive film",
            "subject_type": "Formulation",
            "relationship": "CONTAINS",
            "object": "quercetin",
            "object_type": "Molecule",
            "evidence": "Quercetin/rutin mucoadhesive film",
            "confidence": 1
        },
        {
            "subject": "quercetin/rutin mucoadhesive film",
            "subject_type": "Formulation",
            "relationship": "CONTAINS",
            "object": "rutin",
            "object_type": "Molecule",
            "evidence": "Quercetin/rutin mucoadhesive film",
            "confidence": 1
        }
    ]
}