Wheatgrass molecules systematic review and meta-analysis ( clinical ) Ai Report.docx

Review each suggested relationship below. Accept it if it looks right, edit it to fix a mistake, or reject it if it is wrong. Only accepted relationships will appear on the knowledge map. Rows marked "requires review" are not deleted or blocked - they are just flagged for a closer look.

Subject	Relationship	Object	Evidence	Evidence Stance	AI Extraction Confidence	Status
chlorophyll Molecule	is associated with	oral cancer Disease	Intervention (PICO formulation): In adults with oral cancer or oral potentially malignant disorders (OPMDs), does local delivery (oral strip/film/lozenge) of chlorophyll or chlorophyllin...alter clinical, histologic, or biomarker outcomes Intervention (PICO formulation): In adults with oral cancer or oral potentially malignant disorders (OPMDs), does local delivery (oral strip/film/lozenge) of chlorophyll or chlorophyllin...alter clinical, histologic, or biomarker outcomes	Supports	95% Claim basis	Accepted
chlorophyllin Molecule	is associated with	oral cancer Disease	Intervention (PICO formulation): In adults with oral cancer or oral potentially malignant disorders (OPMDs), does local delivery (oral strip/film/lozenge) of chlorophyll or chlorophyllin...alter clinical, histologic, or biomarker outcomes Intervention (PICO formulation): In adults with oral cancer or oral potentially malignant disorders (OPMDs), does local delivery (oral strip/film/lozenge) of chlorophyll or chlorophyllin...alter clinical, histologic, or biomarker outcomes	Supports	95% Claim basis	Accepted
apigenin Molecule	is associated with	oral cancer Disease	Intervention (PICO formulation): In adults with oral cancer or oral potentially malignant disorders (OPMDs), does local delivery...of apigenin (or flavonoid-rich extracts)...alter clinical, histologic, or biomarker outcomes Intervention (PICO formulation): In adults with oral cancer or oral potentially malignant disorders (OPMDs), does local delivery...of apigenin (or flavonoid-rich extracts)...alter clinical, histologic, or biomarker outcomes	Supports	95% Claim basis	Accepted
quercetin Molecule	is associated with	oral cancer Disease	Intervention (PICO formulation): In adults with oral cancer or oral potentially malignant disorders (OPMDs), does local delivery...of quercetin/rutin...alter clinical, histologic, or biomarker outcomes Intervention (PICO formulation): In adults with oral cancer or oral potentially malignant disorders (OPMDs), does local delivery...of quercetin/rutin...alter clinical, histologic, or biomarker outcomes	Supports	95% Claim basis	Accepted
rutin Molecule	is associated with	oral cancer Disease	Intervention (PICO formulation): In adults with oral cancer or oral potentially malignant disorders (OPMDs), does local delivery...of quercetin/rutin...alter clinical, histologic, or biomarker outcomes Intervention (PICO formulation): In adults with oral cancer or oral potentially malignant disorders (OPMDs), does local delivery...of quercetin/rutin...alter clinical, histologic, or biomarker outcomes	Supports	95% Claim basis	Accepted
abscisic acid Molecule	is associated with	oral cancer Disease	Intervention (PICO formulation): In adults with oral cancer or oral potentially malignant disorders (OPMDs), does local delivery...of abscisic acid...alter clinical, histologic, or biomarker outcomes Intervention (PICO formulation): In adults with oral cancer or oral potentially malignant disorders (OPMDs), does local delivery...of abscisic acid...alter clinical, histologic, or biomarker outcomes	Supports	95% Claim basis	Accepted
chlorophyllin Molecule	modulates Scientific relationship requires review Expected pattern: Molecule/Drug -> MODULATES -> Protein/Pathway	oxidative-stress markers Biomarker	Chlorophyllin and chlorophyll derivatives are antioxidants and radioprotective agents that may modulate oxidative-stress—relevant to carcinogenesis Chlorophyllin and chlorophyll derivatives are antioxidants and radioprotective agents that may modulate oxidative-stress—relevant to carcinogenesis	Supports	85% Claim basis	Pending
chlorophyll Molecule	modulates Scientific relationship requires review Expected pattern: Molecule/Drug -> MODULATES -> Protein/Pathway	oxidative-stress markers Biomarker	Chlorophyllin and chlorophyll derivatives are antioxidants and radioprotective agents that may modulate oxidative-stress—relevant to carcinogenesis Chlorophyllin and chlorophyll derivatives are antioxidants and radioprotective agents that may modulate oxidative-stress—relevant to carcinogenesis	Supports	85% Claim basis	Pending
apigenin Molecule	modulates	NF-κB Protein	apigenin, quercetin, and rutin have demonstrated anti-proliferative, pro-apoptotic, anti‑inflammatory and anti‑invasion effects in oral-cancer cellular and animal models, frequently modulating NF-κB, EGFR/STAT3, PI3K/Akt and MMP pathways apigenin, quercetin, and rutin have demonstrated anti-proliferative, pro-apoptotic, anti‑inflammatory and anti‑invasion effects in oral-cancer cellular and animal models, frequently modulating NF-κB, EGFR/STAT3, PI3K/Akt and MMP pathways	Supports	90% Claim basis	Accepted
quercetin Molecule	modulates	NF-κB Protein	apigenin, quercetin, and rutin have demonstrated anti-proliferative, pro-apoptotic, anti‑inflammatory and anti‑invasion effects in oral-cancer cellular and animal models, frequently modulating NF-κB, EGFR/STAT3, PI3K/Akt and MMP pathways apigenin, quercetin, and rutin have demonstrated anti-proliferative, pro-apoptotic, anti‑inflammatory and anti‑invasion effects in oral-cancer cellular and animal models, frequently modulating NF-κB, EGFR/STAT3, PI3K/Akt and MMP pathways	Supports	90% Claim basis	Accepted
rutin Molecule	modulates	NF-κB Protein	apigenin, quercetin, and rutin have demonstrated anti-proliferative, pro-apoptotic, anti‑inflammatory and anti‑invasion effects in oral-cancer cellular and animal models, frequently modulating NF-κB, EGFR/STAT3, PI3K/Akt and MMP pathways apigenin, quercetin, and rutin have demonstrated anti-proliferative, pro-apoptotic, anti‑inflammatory and anti‑invasion effects in oral-cancer cellular and animal models, frequently modulating NF-κB, EGFR/STAT3, PI3K/Akt and MMP pathways	Supports	90% Claim basis	Accepted
apigenin Molecule	modulates	STAT3 Protein	apigenin, quercetin, and rutin have demonstrated anti-proliferative, pro-apoptotic, anti‑inflammatory and anti‑invasion effects in oral-cancer cellular and animal models, frequently modulating NF-κB, EGFR/STAT3, PI3K/Akt and MMP pathways apigenin, quercetin, and rutin have demonstrated anti-proliferative, pro-apoptotic, anti‑inflammatory and anti‑invasion effects in oral-cancer cellular and animal models, frequently modulating NF-κB, EGFR/STAT3, PI3K/Akt and MMP pathways	Supports	90% Claim basis	Accepted
quercetin Molecule	modulates	STAT3 Protein	apigenin, quercetin, and rutin have demonstrated anti-proliferative, pro-apoptotic, anti‑inflammatory and anti‑invasion effects in oral-cancer cellular and animal models, frequently modulating NF-κB, EGFR/STAT3, PI3K/Akt and MMP pathways apigenin, quercetin, and rutin have demonstrated anti-proliferative, pro-apoptotic, anti‑inflammatory and anti‑invasion effects in oral-cancer cellular and animal models, frequently modulating NF-κB, EGFR/STAT3, PI3K/Akt and MMP pathways	Supports	90% Claim basis	Accepted
rutin Molecule	modulates	STAT3 Protein	apigenin, quercetin, and rutin have demonstrated anti-proliferative, pro-apoptotic, anti‑inflammatory and anti‑invasion effects in oral-cancer cellular and animal models, frequently modulating NF-κB, EGFR/STAT3, PI3K/Akt and MMP pathways apigenin, quercetin, and rutin have demonstrated anti-proliferative, pro-apoptotic, anti‑inflammatory and anti‑invasion effects in oral-cancer cellular and animal models, frequently modulating NF-κB, EGFR/STAT3, PI3K/Akt and MMP pathways	Supports	90% Claim basis	Accepted
apigenin Molecule	modulates	EGFR Protein	apigenin, quercetin, and rutin have demonstrated anti-proliferative, pro-apoptotic, anti‑inflammatory and anti‑invasion effects in oral-cancer cellular and animal models, frequently modulating NF-κB, EGFR/STAT3, PI3K/Akt and MMP pathways apigenin, quercetin, and rutin have demonstrated anti-proliferative, pro-apoptotic, anti‑inflammatory and anti‑invasion effects in oral-cancer cellular and animal models, frequently modulating NF-κB, EGFR/STAT3, PI3K/Akt and MMP pathways	Supports	90% Claim basis	Accepted
quercetin Molecule	modulates	EGFR Protein	apigenin, quercetin, and rutin have demonstrated anti-proliferative, pro-apoptotic, anti‑inflammatory and anti‑invasion effects in oral-cancer cellular and animal models, frequently modulating NF-κB, EGFR/STAT3, PI3K/Akt and MMP pathways apigenin, quercetin, and rutin have demonstrated anti-proliferative, pro-apoptotic, anti‑inflammatory and anti‑invasion effects in oral-cancer cellular and animal models, frequently modulating NF-κB, EGFR/STAT3, PI3K/Akt and MMP pathways	Supports	90% Claim basis	Accepted
rutin Molecule	modulates	EGFR Protein	apigenin, quercetin, and rutin have demonstrated anti-proliferative, pro-apoptotic, anti‑inflammatory and anti‑invasion effects in oral-cancer cellular and animal models, frequently modulating NF-κB, EGFR/STAT3, PI3K/Akt and MMP pathways apigenin, quercetin, and rutin have demonstrated anti-proliferative, pro-apoptotic, anti‑inflammatory and anti‑invasion effects in oral-cancer cellular and animal models, frequently modulating NF-κB, EGFR/STAT3, PI3K/Akt and MMP pathways	Supports	90% Claim basis	Accepted
apigenin Molecule	modulates	PI3K/Akt Pathway	apigenin, quercetin, and rutin have demonstrated anti-proliferative, pro-apoptotic, anti‑inflammatory and anti‑invasion effects in oral-cancer cellular and animal models, frequently modulating NF-κB, EGFR/STAT3, PI3K/Akt and MMP pathways apigenin, quercetin, and rutin have demonstrated anti-proliferative, pro-apoptotic, anti‑inflammatory and anti‑invasion effects in oral-cancer cellular and animal models, frequently modulating NF-κB, EGFR/STAT3, PI3K/Akt and MMP pathways	Supports	90% Claim basis	Accepted
quercetin Molecule	modulates	PI3K/Akt Pathway	apigenin, quercetin, and rutin have demonstrated anti-proliferative, pro-apoptotic, anti‑inflammatory and anti‑invasion effects in oral-cancer cellular and animal models, frequently modulating NF-κB, EGFR/STAT3, PI3K/Akt and MMP pathways apigenin, quercetin, and rutin have demonstrated anti-proliferative, pro-apoptotic, anti‑inflammatory and anti‑invasion effects in oral-cancer cellular and animal models, frequently modulating NF-κB, EGFR/STAT3, PI3K/Akt and MMP pathways	Supports	90% Claim basis	Accepted
rutin Molecule	modulates	PI3K/Akt Pathway	apigenin, quercetin, and rutin have demonstrated anti-proliferative, pro-apoptotic, anti‑inflammatory and anti‑invasion effects in oral-cancer cellular and animal models, frequently modulating NF-κB, EGFR/STAT3, PI3K/Akt and MMP pathways apigenin, quercetin, and rutin have demonstrated anti-proliferative, pro-apoptotic, anti‑inflammatory and anti‑invasion effects in oral-cancer cellular and animal models, frequently modulating NF-κB, EGFR/STAT3, PI3K/Akt and MMP pathways	Supports	90% Claim basis	Accepted
apigenin Molecule	modulates	MMP Protein	apigenin, quercetin, and rutin have demonstrated anti-proliferative, pro-apoptotic, anti‑inflammatory and anti‑invasion effects in oral-cancer cellular and animal models, frequently modulating NF-κB, EGFR/STAT3, PI3K/Akt and MMP pathways apigenin, quercetin, and rutin have demonstrated anti-proliferative, pro-apoptotic, anti‑inflammatory and anti‑invasion effects in oral-cancer cellular and animal models, frequently modulating NF-κB, EGFR/STAT3, PI3K/Akt and MMP pathways	Supports	90% Claim basis	Accepted
quercetin Molecule	modulates	MMP Protein	apigenin, quercetin, and rutin have demonstrated anti-proliferative, pro-apoptotic, anti‑inflammatory and anti‑invasion effects in oral-cancer cellular and animal models, frequently modulating NF-κB, EGFR/STAT3, PI3K/Akt and MMP pathways apigenin, quercetin, and rutin have demonstrated anti-proliferative, pro-apoptotic, anti‑inflammatory and anti‑invasion effects in oral-cancer cellular and animal models, frequently modulating NF-κB, EGFR/STAT3, PI3K/Akt and MMP pathways	Supports	90% Claim basis	Accepted
rutin Molecule	modulates	MMP Protein	apigenin, quercetin, and rutin have demonstrated anti-proliferative, pro-apoptotic, anti‑inflammatory and anti‑invasion effects in oral-cancer cellular and animal models, frequently modulating NF-κB, EGFR/STAT3, PI3K/Akt and MMP pathways apigenin, quercetin, and rutin have demonstrated anti-proliferative, pro-apoptotic, anti‑inflammatory and anti‑invasion effects in oral-cancer cellular and animal models, frequently modulating NF-κB, EGFR/STAT3, PI3K/Akt and MMP pathways	Supports	90% Claim basis	Accepted
chlorophyllin oral strip Formulation	contains	chlorophyllin Molecule	Chlorophyllin oral strip, dose/frequency/duration Chlorophyllin oral strip, dose/frequency/duration	Supports	100% Claim basis	Accepted
quercetin/rutin mucoadhesive film Formulation	contains	quercetin Molecule	Quercetin/rutin mucoadhesive film Quercetin/rutin mucoadhesive film	Supports	100% Claim basis	Accepted
quercetin/rutin mucoadhesive film Formulation	contains	rutin Molecule	Quercetin/rutin mucoadhesive film Quercetin/rutin mucoadhesive film	Supports	100% Claim basis	Accepted

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